Layman summary with societal impact The revised criteria for diagnosing patients with NF1 emphasize the importance of genetic variant detection. This research focuses on optimizing current techniques to efficiently and precisely identify variants in potential NF1 patients, which could be a very helpful tool in diagnosis. The ability to detect …

With this research, the fields of proteomics and bioinformatics could be significantly advanced through improved data pre-processing, leading to enhanced LC-MS data quality. By effectively calibrating proteomics data, this study enables more accurate peptide and protein identification, as well as improved post-translational modification (PTM) analysis. Enhanced PTM identification rates could …

This study focuses on rather fundamental research concepts and is therefore further removed from a direct societal impact than translational research. However, this study aims to provide insights into how we can analyse metaproteomic samples with more certainty and accuracy. This is vital if we want to gather truthful and …

Advanced hepatocellular carcinoma (HCC) remains one of the main causes of cancer death worldwide and was reported by the Surveillance Epidemiology End Results (SEER) as the ‘fastest increasing cause of cancer-related death’. In Belgium, the number of new diagnoses increased from 277 in 2004 to 761 in 2021 (Belgian Cancer …

Advanced hepatocellular carcinoma (HCC) remains one of the main causes of cancer death worldwide and was reported by the Surveillance Epidemiology End Results (SEER) as the ‘fastest increasing cause of cancer-related death’. In Belgium, the number of new diagnoses increased from 277 in 2004 to 761 in 2021 (Belgian Cancer …

Pregnancy complications continue to be a huge burden on prenatal healthcare systems and pregnant women and their fetuses. Today, there is still a lack of accurate screening methods to predict pregnancy complications, such as preeclampsia, early on in pregnancy. Advancements in prenatal screening methods can provide significant benefits to pregnant …

Via deze masterproef wordt de prognostische waarde van hartritmevariabiliteit (HRV) onderzocht bij mensen die een AMI doorgemaakt hebben. Kan de HRV, berekend op basis van een ECG-ritmestrook van 10 seconden, gebruikt worden om de mortaliteit of morbiditeit na STEMI of NSTEMI te voorspellen? De HRV wordt berekend aan de hand …

Beschrijving van de data achter de de wijzigingen in GINA richtlijnen doorheen de jaren voor de behandeling van mild en matig astma.

Deze thesis vormt de basis ter uitwerking van een standaardintegratie van palliatieve zorgen tijdens fase I klinisch onderzoek voor patiënten met kanker. Het betreft kwalitatief onderzoek uitgevoerd via semigestructureerd interviews met onderzoekers, oncologen, medewerkers van de dienst palliatieve zorg en patiënten met kanker in fase I studies. Het onderzoek gaat …

Deze retrospectieve studie onderzoekt de effectiviteit en veiligheid van autologe stamceltransplantatie in de behandeling van pediatrische hersentumoren. Dit gebeurt via analyse van de overall survival, event free survival en de kwaliteit van leven in lange termijn overlevers.