Organoids are a type of 3D tissue culture derived from stem cells, recapitulating the architecture and composition of the tissue of origin. The extracellular matrix (ECM) used to embed and support organoid growth in vitro strongly influences their development. To date, the most used matrix is Matrigel. Matrigel is derived …

Our research focuses on the discovery of small molecules (compounds), which can disrupt the interaction between MEF2C and DNA. When there is an overexpression of MEF2C it causes a challenging form of blood cancer called immature acute leukemia. Previously, targeting transcription factors such as MEF2C seemed impossible because of their …

This study in peptide characterization plays a pivotal role in advancing the accuracy and efficiency of peptide identification. Even though this research is fundamental, each step forward in understanding peptides and proteins brings us closer to practical applications in drug development, biomarker discovery, and new diagnostic tools. The incorporation of …

Inflammatory Bowel Disease (IBD) includes Crohn’s disease and ulcerative colitis (UC), which cause severe inflammation in the gastro-intestinal tract. Symptoms including rectal bleeding, weight loss, and abdominal pain significantly impact patient well-being, leading to stress, anxiety, depression, and can result in severe complications such as infections, cancer, and eventually death. …

This study focusses on using new machine learning approaches to study cell contents at different levels, called omics. Evaluating tissue specific patterns of different omics and the relation between the different levels, could hold significant promise in several sectors. Understanding how various omics work together to create tissue specific functions, …

The global prevalence of overweight individuals has reached a staggering 2.5 billion, of which 890 million are classified as having obesity, putting them at risk of severe health complications such as type 2 diabetes, cardiovascular diseases and cancer. The obesity epidemic poses a pressing public health concern, contributing to increased …

Cardiovascular diseases (CVDs) have high morbidity and mortality rates worldwide. Acute myocardial infarction (MI) is one of the CVDs that occurs when a blood clot obstructs the arteries. Patients who have suffered from an MI frequently have heart failure, which can lead to death. It also greatly affects the quality …

Introduction - Soft tissue sarcomas (STS) are rare malignant tumors arising from connective tissues. They have more than 70 subtypes and very few of them are therapeutically targeted. Hardly any drug trials for potential drug therapies are succeeding because in vitro models fail to represent their effects in a precisely …

Diabetic peripheral neuropathy (DPN) arises from diabetes-induced nerve damage, primarily impacting peripheral nerves. This damage often leads to symptoms such as numbness, tingling, and pain in the lower extremities. Additionally, it affects muscles, causing muscle weakness, loss, and alterations in muscle fiber type composition. By examining these changes, researchers can …

The paediatric chronic kidney disease (CKD) zebrafish models that will be generated based on initial results from this project can be used to better understand the pathophysiology of the disease and perform high-throughput drug screens to identify compounds that can ameliorate the phenotype of the disease. This can lead to …