Tooth decay and inflammation of the tooth’s inner tissue (pulpitis) are common problems that affect people worldwide, often leading to pain and tooth loss. The standard treatment, root canal therapy, removes all living tissue from the tooth. While effective, it results in a non-vital tooth that may weaken over time …

Proteins in our cells are often modified with chemical tags that can act like on/off switches, controlling virtually every cellular process. Understanding these modifications is crucial for medical research, but current technologies face a major bottleneck. When scientists use advanced instruments called mass spectrometers to identify these modifications, they must …

Cerebral microbleeds are tiny bleedings in the brain linked to stroke, dementia and age-related cognitive decline. Understanding how and why they develop is essential for preventing long-term brain damage. However, progress has been limited by the lack of animal models. This research developed a new rat model using a compound …

This dissertation presents the optimization of an analytical method for the quantification and identification of IGF-1, a biomarker associated with the exogenous administration of growth hormone. The refined method enhances the robustness, practical applicability and allows identification of the component, thereby contributing to the advancement of anti-doping efforts. The societal …

The societal impact of this project is profound, with the potential to revolutionize cancer detection and treatment. By using advanced sequencing technologies, early cancer detection might be possible through a blood test that detects signs of cancer, including tumor cells and cell free DNA originating from cancer cells. This method …

Cardiomyopathies such as ACM and MFS represent life-threatening conditions with limited curative options, particularly in young individuals. Understanding the cellular and metabolic underpinnings of these diseases is vital for developing more precise diagnostic and therapeutic strategies. By employing patient-specific hiPSC-derived CMs, this study contributes to a growing body of research …

The field of tissue engineering aims to create models that closely mimic the structure of native tissues. This to gain better insights into the cellular and molecular events happening in our tissues. A critical aspect of these models is the cellular microenvironment, which is defined by multiple factors, including the …

Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) is a rare metabolic disorder affecting fat oxidation. This pilot study investigates the safety and metabolic response to high-intensity exercise in children with MCADD compared to healthy controls. Blood samples are analyzed for various biomarkers, and respiratory exchange ratio is measured. The goal is to …

Teeth play an important role in our daily lives, helping us chew food and speak clearly. If they are not taken care of properly, problems such as cavities and gum disease can develop. These problems not only have a huge impact on the quality of live but also place a …

Despite decades of progress, HIV infection remains a major global health challenge, affecting nearly 40 million people worldwide. Current treatments require lifelong daily medication and do not eliminate the virus from the body. This places a continuous burden on healthcare systems, patients, and society. This thesis explores a next-generation immunotherapy …