Low frequency optogenetic stimulation for suppression of spontaneous seizures in the intrahippocampal kainic acid mouse model

Bryssinck Jordy, 2022
It is clear that epilepsy is a condition which has a huge impact on the patients' quality of life. For example, patients are not allowed to drive a car, some sports cannot be practiced, the constant "fear" of having a seizure at any time... The current treatments are far from suitable for every patient or have many adverse effects. A totally new treatment method could provide a tremendous help to these patients. Optogenetics is a good candidate for this because it offers a number of advantages that could greatly increase the patients' comfort. First, the technique is much more specific because of the gene therapy, this ensures that side effects will be less compared to systemic administration of medication. However, it should be noted that gene therapy itself is still a technique with risks attached. So this technique will also have to be optimized first. Second, the patient also no longer has to make sure that he/she takes their medication on time themselves. It could also be an advantage for surgeons, since resective surgeries are often complex. If optogenetics can be developed further, implantation of a device (to administer light) under the skull should be sufficient. The device will certainly not be cheap but on the other hand, in the long run it may be cheaper than medication that has to be taken daily. If patients have fewer side effects and/or seizures, he/she will also be able to return to work. This will also reduce the burden on society.

Promotor Paul Boon
Opleiding Biomedische Wetenschappen
Domein Neurosciences
Kernwoorden Medial temporal lobe epilepsy optical low frequency stimulation ChRmine WiChR